Endocrine Abstracts

Case history: 48 year old man presented in the endocrinology clinic for further evaluation of hypertension (HTN). He had a hospital admission 2 months ago with worsening dyspnoea and markedly elevated BP (236/149 mmHg). He denied any visual disturbances or chest pain. There were no symptoms to suggest any endocrinopathy. His PMH included previous inguinal hernia repair. He was not on regular medications and he had no allergies. He lived with his family, worked as a manager and...

Introduction: We describe a case of a 29 year old man who was referred to endocrinology services with a 4 month history of erectile dysfunction, decreased libido and low testosterone. He denied symptoms suggestive of pituitary pathology. And he had no previous testicular infections or trauma. His past medical history included asthma, which was well controlled with b-agonist inhaler as required. He had normal development. He was a non smoker, abstinent from alcohol and a keen c...

We report the case of a 65 year old lady who was admitted to A&E with neurological symptoms (slurred speech, ataxia, intermittent confusion) and she was found to have low sodium (116 mmol/l). She reported 2–3 week history of lethargy and lightheadedness. There was no history of shortness of breath, cough, haemoptysis, weight loss, night sweats, altered bowel habits or excessive fluid intake. Her past medical history included hip osteoarthritis and dyslipidaemia. She l...

Background: There exists low confidence in prescription of multiple daily injections (MDI) for newly diagnosed Type 1 Diabetes Mellitus paediatric patients among paediatric doctors at Basildon & Thurrock University Hospital (BTUH).Aim: To improve the confidence in MDI discharge prescriptions for paediatric doctors of all grades via adaptation of local guidelines.Methods: We des...

Background: There are very few studies comparing glycaemic control in patients with different basal rates on Continuous Subcutaneous Insulin Infusion therapy (CSII), so the ideal number of basal rates for a patient is not clear.Objective: To compare the glycaemic control between patients with different basal rates.Methods: Data were collected from hospital’s database and by contacting patients via phone....

Introduction: Primary pituitary sarcoma causally unrelated to radiotherapy, but an increased risk of second brain tumors continues beyond 20 and 30 year after treatment.We report an acromegalic patient with intrasellar giant adenoma invased suprasellar and nasal cavity during follow-up after radiotherapy.Case: A 39-year-old woman had transsphenoidal and transcranial operation in 2002 and 2003 respectively. She had also conventional...

Introduction: Common polymorphisms of the fat mass and obesity associated gene (FTO) is known to associate with increased obesity and diabetes mellitus type 2. This was the first study to investigate the association between the rs9939609 FTO gene polymorphism and gestational diabetes mellitus (GDM) in Turkish women.Patients and methods: The case-control study included 203 gestational diabetes and 191 non-diabetic pregnant controls. Anthropometric and bio...

Back ground: Our Cortisol assay was changed from older generation assay to new second-generation Roche cortisol assay for the Short synacthen tests. There is ~ 20–25% difference in cortisol values between these assays. There are debates about the cut off values for normal response (cortisol of 420 or 440 nmols), compared to 550 nmols/l with older assay. And to assess the use of 30 and 60 min cortisol response.Methods: Short synacthen tests data were...

Background: Dose adjustment for normal eating (DAFNE) structured education programme is an effective tool in improving glycaemic control in patients with type 1 diabetes while reducing the frequency of hypoglycemic episodes. DAFNE however, does not solve all glucose related problems and patients often request or are recommended continuous subcutaneous insulin infusion (CSII) therapy post DAFNE.Objective: Out of our 370 DAFNE graduates, 46 have subsequent...

Background: SIADH is the most frequent underlying cause of hyponatraemia but is frequently ignored and suboptimally treated.Aim: To identify the treatment applied in clinical practice for hyponatraemia due to SIADH and to evaluate the effect of fluid deprivation.Method: A prospective, non-intervention observational study of a sequentially evaluated cohort of hyponatraemic patients during first 48 h after hospitalization from Januar...